Amebiasis, caused by Entamoeba histolytica, can lead to severe long-term effects if left untreated. Chronic infection may cause persistent diarrhea, malabsorption, and weight loss. In severe cases, it can result in liver abscesses, which may lead to liver damage or rupture. Intestinal complications like strictures and perforations can occur, leading to peritonitis. Early treatment with antiparasitic medications such as nizonide 500mg (nitazoxanide) can help eliminate the infection and prevent complications. Without proper medical intervention, amebiasis may contribute to long-term gastrointestinal disorders and systemic infections, impacting overall health. Seeking timely medical advice is crucial for managing and preventing recurrence.